Mathematical modeling of infectious disease and designing vaccination law for control of this diseases

In this paper, we propose the concept of partial stability instead of that of global stability to deal with the stability issues of epidemic models. The partial stability is able to provide a more meaningful analysis of the problem since it only focuses on the behavior of some of the variables (infected and infectious) instead of the complete population. It has been shown that the vaccination free SEIR model can still be partially stable even when a globally stability property does not hold, for two types of nonlinear incidence rates. By introducing the concept of partial stability and by designing a control vaccination based on it. Guarantee the eradication of an epidemic disease without requiring the global stability of the epidemic model

Designing an appropriate adaptive controller for synchronizing a bi-oscillator heart model with time delay

In this paper, synchronization of heart follower oscillator which has lower frequency AV with heart leader oscillator which has dominant frequency SA will be studied. It can be seen if two nodes SA and AV are not synchronized, different types of cardiac blocking arrhythmias occur. Thus, in this paper, beside putting voltage to node SA, by applying time delay in bi-oscillator model of heart system and designing appropriate controller via linear and adaptive methods, we try to prevent blocking arrhythmias of heart. Finally, we apply Lyapanuv stability theorem for ensuring convergence

Evolving GANs: When Contradictions Turn into Compliance

Limited availability of labeled-data makes any supervised learning problem challenging. Alternative learning settings like semi-supervised and universum learning alleviate the dependency on labeled data, but still require a large amount of unlabeled data, which may be unavailable or expensive to acquire. GAN-based synthetic data generation methods have recently shown promise by generating synthetic samples to improve task at hand. However, these samples cannot be used for other purposes. In this paper, we propose a GAN game which provides improved discriminator accuracy under limited data settings, while generating realistic synthetic data. This provides the added advantage that now the generated data can be used for other similar tasks. We provide the theoretical guarantees and empirical results in support of our approach.Comment: Generative Adversarial Networks, Universum Learning, Semi-Supervised Learnin

3D Motion Reconstruction from 2D Motion Data Using Multimodal Conditional Deep Belief Network

In this paper, we propose a deep generative model named Multimodal Conditional Deep Belief Network (MCDBN) for cross-modal learning of 3D motion data and their non-injective 2D projections on the image plane. This model has a three sectional structure, which learns conditional probability distribution of 3D motion data given 2D projections. Two distinct Conditional Deep Belief Networks (CDBNs), encode the real-valued spatiotemporal patterns of 2D and 3D motion time series captured from subjects’ movements into the compact representations. The third part includes a Multimodal Restricted Boltzmann Machines (MRBMs) which in the training process, learns the relationship between the compact representations of data modalities by variation information criteria. As a result, conditioned on a 2D motion data obtained from a video, MCDBN can regenerate 3D motion data in generation phase. We introduce Pearson correlation coefficient of ground truth and regenerated motion signals as a new evaluation metric in motion reconstruction problems. The model is trained with human motion capture data and the results show that the real and the regenerated signals are highly correlated which means the model can reproduce dynamical patterns of motion accurately

A Case Report of Multifocal Epithelial Hyperplasia (Heck's Disease) Treated with CO2 Laser

Focal epithelial hyperplasia or Heck’s disease is a rare benign lesion of oral mucosa caused by human papilloma virus especially subtypes 13 and 32. The disease is predominantly found in children and adolescents with indigenous heritage. This paper reports a unique case of Heck's disease in an 11-year-old Iranian girl with multiple, bilateral and elevated lesions on the buccal and labial mucosa. The lesions had persisted for a year. The disease was diagnosed as focal epithelial hyperplasia through the clinical examination. Considering esthetic and functional problems, CO2 laser (Wavelength: 10600 nm) surgery was determined as a suitable choice of treatment. The patient was followed up over 1 year with no signs of lesion recurrence

The prevalence of smoking among the population in the city of Mashhad (north east of Iran) and pulmonary function tests among smokers

Introduction: Smoking is known as a major cause of chronic obstructive pulmonary disease (COPD). In this study the prevalence of smoking in the population of Mashhad city was evaluated as well as pulmonary function tests (PFTs) of smokers. Material and methods: The prevalence of smoking was studied using a standard questionnaire. Pulmonary function tests, including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), maximal mid-expiratory flow (MMEF), peak expiratory flow (PEF), and maximal expiratory flow at 75%, 50%, and 25% of the FVC (MEF75,50,25), were measured in all smokers. Results: In total, 1435 individuals were interviewed including 999 males and 436 females. The number of smokers among the interviewed individuals was 183 (12.7%) including 172 male (17.2%) and 11 female (2.5%). The results showed that all values of PFTs in smokers were reduced. There were significant negative correlations between smoking duration and rate as pack/year and values of PFT (p < 0.05). Conclusions: In this study the prevalence of smoking in the population of Mashhad city was shown for the first time. The effect of smoking on PFTs showed that smoking leads to constriction of large and medium airways, which is due to duration and rate of smoking. Pneumonol. Alergol. Pol. 2011; 79, 1: 21-25Wstęp: Palenie tytoniu jest główną przyczyną przewlekłej obturacyjnej choroby płuc. Celem niniejszego badania było określenie rozpowszechnienia palenia tytoniu w populacji miasta Mashhad oraz przeprowadzenie testów czynnościowych płuc u osób palących. Materiał i metody: Rozpowszechnienie palenia tytoniu określono za pomocą standardowego kwestionariusza. U wszystkich osób palących wykonano badania czynnościowe płuc obejmujące pomiar natężonej pojemności życiowej (FVC), natężonej objętości wydechowej pierwszosekundowej (FEV1), przepływu środkowowydechowego (MMEF), szczytowego przepływu wydechowego (PEF) i maksymalnego przepływu wydechowego przy FVC równej 75, 50 i 25% (MEF75, 50, 25). Wyniki: W badaniu wzięło udział 1435 osób, 999 mężczyzn i 436 kobiet. Palenie tytoniu zadeklarowały 183 (12,7%) osoby spośród respondentów - 172 mężczyzn (17,2%) i 11 kobiet (2,5%). Wszystkie wyniki badań czynnościowych płuc u osób palący były obniżone. Zaobserwowano istotą ujemną korelację między czasem palenia tytoniu i liczbą paczek papierosów wypalanych w ciągu roku a parametrami ocenianymi w badaniach czynnościowych (p < 0,05). Wnioski: W niniejszym badaniu po raz pierwszy oceniono odsetek osób palących w populacji Mashhadu. Ocena parametrów czynnościowych płuc wykazała, że palenie tytoniu prowadzi do zwężenia dużych i średnich oskrzeli, a efekt ten zależy od długości okresu palenia i od liczby wypalanych papierosów. Pneumonol. Alergol. Pol. 2011; 79, 1: 21-2

Insilco study of the effect of hesperetin on three pre-apoptotic factors Bad, Bak, Bim

Background and Aim Many compounds derived from medicinal plants, such as antioxidants and polyphenols have significant roles in prevention and treatment of various cancers. Activation of apoptosis related pathways is one of the mechanisms for inhibition of cancer progression. In this study, we investigated the effect of molecular dynamics simulation of hesperetin on the pre-apoptotic factors of Bad, Bak, and Bim. Material and Methods In this study we collected data about 3 dimensional structure and Protein Data Bank (PDB) files of three apoptotic factors of Bad, Bak, and Bim from Protein Data Bank (http://www.rscb.org/pdb). Using VMD v1.9.2, AutoDock v.4.2, and Gromacs v.4.5.4 softwares, we started processes such as optimization, simulation, molecular docking and molecular dynamics calculations. Results Binding of Bad molecule to hesperetin led to release of the highest amount of energy and reduced changes in the radius of gyration of Bad protein. But after binding of Bim and Bak proteins to hesperetin, changes in the radius of gyration, increased. The most frequent change in the secondary protein structure was related to increased amount of Bent structure and decreased amount of β-sheet structure in Bim molecule. Conclusion Hesperetin can affect the activities of pre-apoptotic factors of Bad, Bak, and Bim by influencing their molecular dynamics. It seems that hesperetin has the highest effect on the activation of Bad molecule. Also, it can activate Bim protein and induce apoptosis via inducing alternations in the secondary structure of the protein. Keywords: Molecular dynamic , Apoptosis , Hespereti